Procreate, Pixelmator Pro, Affinity Designer, and Affinity Photo are the 4 apps that I use to create my art.
I have all 4 of these apps on both my iPad Pro 1st Gen and iMac. I use the Apple Pencil exclusively.
The workflow I'm keeping to myself but it's best described as trial and error. I create and if I don't like where it's going I'll delete or clear that layer.